The ProgeNIA/SardiNIA Project

2018-10-24T17:10:29+00:00

Genetics and epidemiology of aging-related traits and diseases in a population cohort: the ProgeNIA / SardiNIA Project Finding longevity genes is only one of many goals for gerontologists. An equally important mission is unraveling the genetic processes involved in age-related traits and diseases. IRGB and NIA are focusing their attention on the Mediterranean island of [...]

The Sardinian Transcriptome Project

2018-06-29T07:34:19+00:00

The Sardinian Transcriptome Project The interpretation of GWAS is extremely challenging since most candidate loci fall in non-coding regions and are difficult to interpret. Given the important role of regulatory variation in shaping phenotypic complexity, expression Quantitative Trait Loci (eQTLs) have been proposed as informative intermediate phenotypes between genomic sequence variation and human [...]

Dissection of the genetic bases of autoimmune diseases in Sardinia

2017-08-04T08:51:49+00:00

The project aims to define the immunological traits whose variation impacts the predisposition to complex diseases and immunosenescence. This is being accomplished by genome wide association studies using ultra-high definition polychromatic flow cytometry of circulating cells The project aims to define the immunological traits whose variation impacts the predisposition to complex diseases and immunosenescence.

The Sardinian Genome Project for medical and human evolution discovery

2017-08-04T08:48:12+00:00

The Sardinian Genome Project for medical and human evolution discovery Next generation sequencing has revolutionized the resolution of genetic analyses. Since 2010, the IRGB institute has exploited this advanced technology with a lowpass sequencing approach aiming at the genetic characterization of the Sardinian population. We sequenced about 3,500 whole genomes discovering more [...]

Immune Deployment Project

2017-08-04T08:47:07+00:00

The project aims to define the immunological traits whose variation impacts the predisposition to complex diseases and immunosenescence. This is being accomplished by genome wide association studies using ultra-high definition polychromatic flow cytometry of circulating cells The project aims to define the immunological traits whose variation impacts the predisposition to complex diseases and immunosenescence.

Induced pluripotent stem cells for disease modelling and regenerative medicine

2017-08-04T08:56:39+00:00

Induced pluripotent stem cells for disease modelling and regenerative medicine. Autosomal recessive osteopetrosis is a human bone disease mainly caused by TCIRG1 gene mutations that prevent osteoclasts resorbing activity, recapitulated by the oc/oc mouse model. Bone marrow transplantation is the only available treatment, limited by the need for a matched donor. The use [...]