Marco Orrù
Cardiologist
Area of interest:
In progress..
Most significant publications:
2020
Scuteri, A.; Morrell, C. H.; Fegatelli, D. A.; Fiorillo, E.; Delitala, A.; Orru', M.; Marongiu, M.; Schlessinger, D.; Cucca, F.
Arterial stiffness and multiple organ damage: a longitudinal study in population Journal Article
In: 32 (5), pp. 781–788, 2020.
@article{pmid31302897,
title = {Arterial stiffness and multiple organ damage: a longitudinal study in population},
author = { A. Scuteri and C. H. Morrell and D. A. Fegatelli and E. Fiorillo and A. Delitala and M. Orru' and M. Marongiu and D. Schlessinger and F. Cucca},
year = {2020},
date = {2020-05-01},
volume = {32},
number = {5},
pages = {781--788},
abstract = {Previous cross-sectional observation identified arterial aging, indexed as pulse-wave velocity (PWV), as a key determinant of the simultaneous multiple organ damage (heart, carotid artery, and kidney). The aim of the present cohort study is to investigate trajectories of repeated measures of PWV and traditional CV risk factors in subjects who eventually presented clinical evidence of multiple organ damage in the SardiNIA study. Organ damage was measured in the heart (left ventricular hypertrophy, LVH), the common carotid artery (intima-media thickness > 0.9 mm and/or plaque), and the kidney (eGFR < 60 ml/min/1.73 m2) of 2130 men and women of a broad age range participating the SardiNIA study. SHATS was defined as the simultaneous occurrence of all the three-organ damages. Trajectory in traditional CV risk factors and PWV was analyzed retrospectively (four observations over 9 years) according to the number of organ damage (from 0 to 3). Compared to subjects with no organ damage, after controlling for traditional CV risk factors, each 1 m/s increase in baseline PWV was accompanied by a 93% higher odds of developing SHATS; and each 1 cm/s (0.01 m/s) annual increase in PWV by a 31% greater odds of developing SHATS. Arterial stiffness, a proxy of arterial aging that can be measured clinically as PWV, is an integrated predictive marker of multiple age-associated organ damage recognized as clinical diseases.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Previous cross-sectional observation identified arterial aging, indexed as pulse-wave velocity (PWV), as a key determinant of the simultaneous multiple organ damage (heart, carotid artery, and kidney). The aim of the present cohort study is to investigate trajectories of repeated measures of PWV and traditional CV risk factors in subjects who eventually presented clinical evidence of multiple organ damage in the SardiNIA study. Organ damage was measured in the heart (left ventricular hypertrophy, LVH), the common carotid artery (intima-media thickness > 0.9 mm and/or plaque), and the kidney (eGFR < 60 ml/min/1.73 m2) of 2130 men and women of a broad age range participating the SardiNIA study. SHATS was defined as the simultaneous occurrence of all the three-organ damages. Trajectory in traditional CV risk factors and PWV was analyzed retrospectively (four observations over 9 years) according to the number of organ damage (from 0 to 3). Compared to subjects with no organ damage, after controlling for traditional CV risk factors, each 1 m/s increase in baseline PWV was accompanied by a 93% higher odds of developing SHATS; and each 1 cm/s (0.01 m/s) annual increase in PWV by a 31% greater odds of developing SHATS. Arterial stiffness, a proxy of arterial aging that can be measured clinically as PWV, is an integrated predictive marker of multiple age-associated organ damage recognized as clinical diseases.
Lakatta, E. G.; AlunniFegatelli, D.; Morrell, C. H.; Fiorillo, E.; Orru, M.; Delitala, A.; Marongiu, M.; Schlessinger, D.; Cucca, F.; Scuteri, A.
Impact of Stiffer Arteries on the Response to Antihypertensive Ŧreatment: A Longitudinal Study of the SardiNIA Cohort Journal Article
In: J Am Med Dir Assoc, 21 (6), pp. 720–725, 2020.
@article{pmid31884052,
title = {Impact of Stiffer Arteries on the Response to Antihypertensive Ŧreatment: A Longitudinal Study of the SardiNIA Cohort},
author = { E. G. Lakatta and D. AlunniFegatelli and C. H. Morrell and E. Fiorillo and M. Orru and A. Delitala and M. Marongiu and D. Schlessinger and F. Cucca and A. Scuteri},
year = {2020},
date = {2020-01-01},
journal = {J Am Med Dir Assoc},
volume = {21},
number = {6},
pages = {720--725},
abstract = {Carotid-femoral pulse wave velocity (PWV), an index of arterial stiffness and a proxy of arterial aging, has been reported to be an independent determinant of cardiovascular health. Whether the effects of antihypertensive treatment vary in the presence of accelerated arterial aging (stiffer artery, ie, PWV >10 m/s) has not been established. We tested this hypothesis in a longitudinal study in a large community-dwelling population. Longitudinal population study with repeated measures. Study population consisted of a cohort of 6011 volunteers (2546 men and 3465 women, age range 14-101 years; 15,011 observations over a median follow-up of 6.8 years) participating in the SardiNIA Study. Repeated measures of PWV, blood pressure (BP), and metabolic risk factors and the antihypertensive medication trajectories of BP and PWV over time were assessed via mixed effects models. Antihypertensive treatment significantly affected the trajectory of BP in both participants with (-0.47 ± 0.20 mmHg/y},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Carotid-femoral pulse wave velocity (PWV), an index of arterial stiffness and a proxy of arterial aging, has been reported to be an independent determinant of cardiovascular health. Whether the effects of antihypertensive treatment vary in the presence of accelerated arterial aging (stiffer artery, ie, PWV >10 m/s) has not been established. We tested this hypothesis in a longitudinal study in a large community-dwelling population. Longitudinal population study with repeated measures. Study population consisted of a cohort of 6011 volunteers (2546 men and 3465 women, age range 14-101 years; 15,011 observations over a median follow-up of 6.8 years) participating in the SardiNIA Study. Repeated measures of PWV, blood pressure (BP), and metabolic risk factors and the antihypertensive medication trajectories of BP and PWV over time were assessed via mixed effects models. Antihypertensive treatment significantly affected the trajectory of BP in both participants with (-0.47 ± 0.20 mmHg/y
2016
Scuteri, A.; Morrell, C. H.; Orru', M.; AlGhatrif, M.; Saba, P. S.; Terracciano, A.; Ferreli, L. A.; Loi, F.; Marongiu, M.; Pilia, M. G.; Delitala, A.; Tarasov, K. V.; Schlessinger, D.; Ganau, A.; Cucca, F.; Lakatta, E. G.
Gender specific profiles of white coat and masked hypertension impacts on arterial structure and function in the SardiNIA study Journal Article
In: Int J Cardiol, 217 , pp. 92–98, 2016.
@article{pmid27179214,
title = {Gender specific profiles of white coat and masked hypertension impacts on arterial structure and function in the SardiNIA study},
author = { A. Scuteri and C. H. Morrell and M. Orru' and M. AlGhatrif and P. S. Saba and A. Terracciano and L. A. Ferreli and F. Loi and M. Marongiu and M. G. Pilia and A. Delitala and K. V. Tarasov and D. Schlessinger and A. Ganau and F. Cucca and E. G. Lakatta},
year = {2016},
date = {2016-01-01},
journal = {Int J Cardiol},
volume = {217},
pages = {92--98},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
- Lanusei
marco.orrù@irgb.cnr.it
0782-480674