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Criteria for the optimal use of genetic findings in the drug discovery pipeline

Genetic-Driven Druggable Target Identification and Validation

Matteo Floris, Stefania Olla, David Schlessinger and Francesco Cucca

Choosing the right biological target is the critical primary decision for the development of new drugs. Systematic genetic association testing of both human diseases and quantitative traits, along with resultant findings of coinci-dent associations between them, is becoming a powerful approach to infer drug targetable candidates and generate in vitro tests to identify compounds that can modulate them therapeutically. Here, we discuss opportunities and challenges, and infer criteria for the optimal use of genetic findings in the drug discovery pipeline.

Read the full article in Trends in Genetics

A schematic roadmap for taking advantage of genetic discoveries to identify drug targets is shown
2018-06-06T08:42:36+00:00 June 6th, 2018|News|