• image

    Genetic Variants Regulating Immune Cell Levels in Health and Disease.

    Fluorescence Activated Cell Sorting (FACS)

    The complex network of specialized cells and molecules in the immune system has evolved to defend against pathogens, but inadvertent immune system attacks on “self” result in autoimmune disease. Both genetic regulation of immune cell levels and their relationships with autoimmunity are largely undetermined. Here, we report genetic contributions to quantitative levels of 95 cell types encompassing 272 immune traits, in a cohort of 1,629 individuals from four clustered Sardinian villages.

     

    Read more...

  • image

    Low-Pass DNA Sequencing of 1200 Sardinians Reconstructs European Y-Chromosome Phylogeny

    Genetic variation within the male-specific portion of the Y chromosome (MSY) can clarify the origins of contemporary populations.

    Population sequencing of 1204 Sardinian males identified 11,763 MSY single-nucleotide polymorphisms, 6751 of which have not previously been observed. We constructed a MSY phylogenetic tree containing all main haplogroups found in Europe, along with many Sardinian-specific lineage clusters within each haplogroup. The tree was calibrated with archaeological data from the initial expansion of the Sardinian population ~7700 years ago. The ages of nodes highlight different genetic strata in Sardinia and reveal the presumptive timing of coalescence with other human populations. We calculate a putative age for coalescence of ~180,000 to 200,000 years ago, which is consistent with previous mitochondrial DNA–based estimates.

     

    Leggi tutto...

  • image

    ProgeNIA

    Epidemiologia e Genetica di alcune condizioni associate con l'invecchiamento nella popolazione Sarda

    In collaborazione con il National Institute on Aging (NIA)/National Institute of Health (NIH)- Batimora USA.

     

    leggi tutto...

Demo Image

 

Home

 

Read more...

Demo Image

 

How to reach us...

 

Read more...

Demo Image

 

Staff

 

Read more...

Demo Image

 

Transparent Administration

 

Continua...

Rate this item
(0 votes)

Mission


The institute is responsible for the identification and the study of function of genes involved in monogenic diseases and complex diseases. The Institute was established as an Institute for Research on Mediterranean Anemia and Thalassemia. Even today one of the main missions involve the study of the regulation of the globin genes and hematopoiesis, improved prevention and treatment of this disease and the development of gene therapy.

Read 115545 times
Copyright © 2017 Institute of Genetic and Biomedical Research - IRGB. All Rights Reserved.
Joomla! is Free Software released under the GNU General Public License.